Nelarabine
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Trade names | Arranon, Atriance |
Other names | 506U78 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607077 |
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Routes of administration | Intravenous |
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Pharmacokinetic data | |
Bioavailability | n/a |
Protein binding | <25% |
Metabolism | By adenosine deaminase, to 9-β-D-arabinofuranosylguanine |
Elimination half-life | 30 minutes (nelarabine) 3 hours (ara-G) |
Excretion | Kidney |
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ECHA InfoCard | 100.170.768 |
Chemical and physical data | |
Formula | C11H15N5O5 |
Molar mass | 297.271 g·mol−1 |
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Nelarabine, sold under the brand names Arranon (US) and Atriance (EU), is a chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).[4][5]
Nelarabine is a prodrug of arabinosylguanine nucleotide triphosphate (araGTP), a type of purine nucleoside analog, which causes inhibition of DNA synthesis and cytotoxicity.[6] Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens.[7] It was later approved in the European Union in October 2005.[5] It is available as a generic medication.[8]
References
[edit]- ^ a b "Nelarabine-Reach". Therapeutic Goods Administration (TGA). 5 June 2024. Retrieved 17 June 2024.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ "Therapeutic Goods (Poisons Standard—June 2024) Instrument 2024". Federal Register of Legislation. 30 May 2024. Retrieved 10 June 2024.
- ^ a b "Arranon- nelarabine injection". DailyMed. 11 June 2020. Retrieved 4 December 2020.
- ^ a b c "Atriance EPAR". European Medicines Agency (EMA). 20 September 2007. Retrieved 4 December 2020.
- ^ "Nelarabine". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.
- ^ Cohen MH, Johnson JR, Justice R, Pazdur R (June 2008). "FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma". The Oncologist. 13 (6): 709–14. doi:10.1634/theoncologist.2006-0017. PMID 18586926. S2CID 23463537.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
External links
[edit]- "Nelarabine". NCI Dictionary of Cancer Terms. National Cancer Institute.
- "Nelarabine". National Cancer Institute.[permanent dead link]